If a worker develops respiratory symptoms consistent with isocyanate exposure, particularly wheezing, coughing or difficulty breathing, a medical practitioner should assess the relationship. Substancepreparation and company identification company 24 hour emergency response information lapolla industries, inc. Material safety data sheet 3mtm single step primer pn 08681, 08682, 08708, 58012 12102008 page 5 of 9 select and use gloves andor protective clothing to prevent skin contact based on the results of an exposure assessment. Signs and symptoms of acute methyl isothiocyanate exposure. Small amounts of methyl isocyanate may evaporate into air. Call a physician or poison control center immediately. If methyl isocyanate is involved in a fire it can release hydrogen cyanide. Aquacast acs through acs 1099 series, and all acsx prefixes, uc 800 through uc 899 series and all ucx prefixes. Methyl isocyanate is rapidly minutes to a few hours degraded in water into other compounds. Material safety data sheet isocyanate mdii a component revised date. Methyl mercaptan 74931 100 may contain trace hydrogen sulfide below 0. Material safety data sheets 389 methyl isocyanate stable water, acid, alkali, amine, iron, tin, copper and their salts, other.
People exposed to high levels of methyl isocyanate in the air have experienced severe lung and eye damage. In order to ensure that chemical manufacturing takes place in a. With the exception of methyl isocyanate which has a low flash point of 7 c, most isocyanates. Methyl isocyanate has been found in at least 1 of the 1,585 national priorities list sites identified by the environmental protection agency epa. The basis for the high reactivity of the isocyanates is the low electron density of the central carbon. In the event of fire, wear selfcontained breathing apparatus. Consult stonhards technical service department for instruction on proper use of. Msds document number si000 revision dated 19 dec 00 in an emergency, call chemtrec at 8004249300 us toll free or 7035273887. All applicants who are assigned to an isocyanate work area should undergo a preplacement medical evaluation. Handling and storage handling general advice if bulging of drum occurs, transfer to well ventilated area, puncture to relieve pressure, open vent, and let stand for.
Carbaryl is an n methyl carbamate that inhibits cholinesterase. Methyl isocyanate is a colorless liquid that has a sharp odor. Methyl isocyanate, classified as a chokingpulmonary agent, is a water reactive liquid at room temperature. Contact with the skin, eyes, and mucous membranes may result in severe irritation and permanent damage.
Individuals with lung or breathing problems or prior reactions to isocyanates must not be exposed to vapors or spray mist of this product. The release of methyl isocyanate mic was the cause of this disaster. Methyl isocyanate is a volatile, colorless liquid with a strong. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. The use and storage of methyl isocyanate mic at bayer cropscience the use of hazardous chemicals such as methyl isocyanate can be a significant concern to the residents of communities adjacent to chemical facilities, but is often an integral, necessary part of the chemical manufacturing process. Synonyms are isocyanatomethane, methyl carbylamine and mic. Workplace exposure1 there is a potential for workplace exposure to mdi in all industrial, commercial, or manufacturing settings where mdi is present. Methylene diphenyl diisocyanate mdi and related compounds. Ld50s for isocyanates are typically several hundred milligrams per kilogram. Methyl isocyanate does not accumulate in the food chain.
Despite this low acute toxicity, an extremely low shortterm exposure limit stel of 0. To receive documents or other information about occupational safety and health topics. This action plan addresses the use of methylene diphenyl diisocyanate mdi and related compounds see appendix 1 in products that may result in consumer and general population. Methyl ethyl ketone has been demonstrated to potentiate i. A meta description is an html tag in the html code of your website, which allows you to customize a section of text that describes the page itself. The use of hazardous chemicals such as methyl isocyanate can be a significant concern to the residents of communities adjacent to chemical facilities, but is often an integral, necessary part of the chemical manufacturing process. Safety data sheets sds and labels should be checked to determine if products used at the. Methylene diphenyl diisocyanate mdi in commercial form typically exists as a mixture of 4,4mdi monomer and certain oligomers of mdi encyclopedia of chemical technology, 1983. A history of eczema or respiratory allergies such as hay fever, are possible reasons for medical exclusion from isocyanate areas. Cdc niosh pocket guide to chemical hazards methyl isocyanate. Methyl isocyanate mis cautionary response information common synonyms liquid colorless sharp, unpleasant odor floats.
Product safety assessment dow modified methyl diphenyl. It plays a role in how your page is seen by search engine crawlers, and how it appears in serps. Acute exposure to methyl isocyanate may result in respiratory tract irritation, cough, chest tightness and pain, dyspnea shortness of breath, asthmatic episodes, and pulmonary edema. Methyl isocyanate substance information hazmat tool. From our library of articles, sigmaaldrich presents hplc analysis of isocyanates on titan c18 keywords. Ou chemical safety data no longer updated more details. Agency for toxic substances and disease registry atsdr, 2002, april. First aid measures remove victim to fresh air and keep at rest in a position comfortable for breathing.
Methyl isocyanate sulphur oxides nitrogen oxides nox precautions for firefighting in the event of fire andor explosion do not breathe fumes. Summary the use and storage of methyl isocyanate mic at. Protocol overview methyl isocyanate, classified as a chokingpulmonary agent, is a water reactive liquid at room temperature. Guide to handling isocyanates table 2 isocyanate exposure to workers work activity source of exposure spraying operations e. Call a poison control center or doctor dilute spill using absorbent or imper open flame tlv. Toxicological information chronic toxicity specific to active ingredients no toxic effects were seen in rats administered up to 200 mgkg of carbaryl for 2 years. Remove contact lenses, irrigate copiously with clean, fresh water, holding the eyelids apart for at least 10 minutes and seek immediate medical advice. October 29, 2014 the dow chemical company page 4 of 7 based on the uses for mdi, the public could be exposed through. Once all components have dropped in temperature,the isocyanate is added and mixed for two minutes. Cas number, unna number, dot hazard label, uscg chris code. October 29, 2014 the dow chemical company page 5 of 7 asthmalike symptoms may include coughing, difficult breathing and a feeling of tightness in the.
Illness may occur rapidly after overexposure to this product. In bhopal, india, accidental acute inhalation exposure to methyl isocyanate resulted in the deaths of about 3,800 people and adverse health effects in greater than. Applicants who have a history of adult asthma should be restricted from work with isocyanates. Not classifiable as to its carcinogenicity to humans group 3.
The principal hazard of this product is reversible cholinesterase inhibition. Methyl isocyanate cas 624839 skin designation applies. Never give anything by mouth to an unconscious or convulsing person. Methyl isocyanate ch3nco or c2h3no cid 12228 structure, chemical. Sigmaaldrich offers an extensive selection of isocyanate derivatives such as aromatic isocyanates e.
In august 2008, an explosion of a pressurized vessel, known as a residue treater, at the bayer cropscience bayer facility in institute, west virginia resulted in the deaths of two plant employees, a fire within the production unit, and extensive damage to nearby structures. Isocyanatomethane isocyanic acid, methyl ester methane, isocyanatomethyl carbonimide mic keep people away. Isocyanates nitrogen compounds organic building blocks. Material safety data sheet msds catalog service llc. Guide for handling isocyanates safe work australia. Msds 12 dupont performance coatings january 1, 2008. Methyl isocyanate is irritating and corrosive to the eyes, skin, and respiratory tract, including asthmalike allergy.
The composition of the reaction product depends on the ratios of the starting materials and on the reaction conditions. The use and storage of methyl isocyanate mic at bayer. Search results for methyl isocyanate at sigmaaldrich. Methyl isocyanate was cleared more rapidly from the urine than from bile. Page 4 lpa isocyanate msds lpa isocyanate continued rev. Isocyanates, a derivative of isocyanic acid, contain the functional group rnco, where r is predominantly an alkyl or aryl, and can include fluorinated, brominated, or chlorinated derivatives. Isocyanates occupational safety and health administration. Methyl isocyanate gas, toxic fumes of cl and oxides of nitrogen hazardous polymerization.
Methyl isocyanate was cleared slowly from the blood. Signs and symptoms of acute exposure to methyl isothiocyanate is an irritant to eyes, skin, lungs, and the mucous membranes of the gastrointestinal tract. First aid measures as this product is a gas, refer to the inhalation section. Air monitoring, chromatography, high performance liquid chromatography, liquid chromatography mass spectrometry, mass spectrometry. Exposure to methyl isocyanate can result in cough, difficulty breathing, chest pain, excessive tearing lacrimation, swelling of the eyes, and unconsciousness. Mar 03, 2011 exposure to low levels of methyl isocyanate can cause eye and throat irritation. Product and company identification isocyanate mdii a component. Safety data sheet based upon regulation ec no 19072006, as amended by regulation eu no 2015830 structan express section 1. The content of monomeric mdi generally is between 45% and 65% on a ww basis mobay, 1983. The highest concentrations of methyl isocyanate in male mice 2 hours after exposure were found in the lung, sternum, gastrointestinal tract, spleen, and kidney.
Thank you for visiting our website you are exiting the department of labors web server. Product safety assessment mdibased isocyanate products. Methyl isothiocyanate is very toxic and highly irritating to skin, mucous membranes, and eyes. Show this material safety data sheet to the doctor in attendance. Uly 2015 5 guide to handling isocyanates difficulty in breathing tightness of the chest, coughing, wheezing and shortness of breath other asthmalike symptoms, and headache and discomfort. Methyl isocyanate is an intermediate chemical in the production of carbamate pesticides such as carbaryl, carbofuran, methomyl, and aldicarb. Signs and symptoms of acute methyl isocyanate exposure. Material safety data sheet lapolla isocyanate lpaiso. These symptoms, which include chest tightness, wheezing, cough, shortness of breath, or asthmatic attack, could be immediate or delayed up to several hours after exposure.
Methyl isocyanate mic will react with water, or in the presence of catalysts such as sodium hydroxide. Identification product identifier methyl isocyanate other means of identification item n12440 synonyms isocyanic acid, methyl ester recommended use for laboratory use only recommended restrictions none known. Mek by itself has not been demonstrated to cause peripheral neuropathy. Breathing methyl isocyanate can irritate the nose and throat. Mic is used as an intermediate in the manufacture of carbamate pesticides, such as carbaryl sevin, carbofuran furadan, curater, methomyl and aldicarb temik. Methyl isocyanate would then be released into the air. Methyl isocyanate mic is an organic compound with the molecular formula ch3nco. Methods for cleaning up stop the leak if it can be done without risk. Methyl isocyanate mic is an organic compound with the molecular formula ch 3 nco. Agency for toxic substances and disease registry atsdr, april 2002. Dow modified methylene diphenyl diisocyanate mdi products revised. To avoid the risk of static discharges and gas ignition, soak contaminated clothing thoroughly with water before removing it. Summarizes the properties and health effects for methyl isocyanate.
Silane msds material safety data sheet for silane sih4 reference. The department of labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. Msds 12 dupont performance coatings january 1, 2008 material. Identification product identifier methyl isocyanate other means of identification item n12440 synonyms isocyanic acid, methyl ester recommended use for laboratory use only. Application methyl isothiocyanate was used to study the effect of pesticide metam methyl isothiocyanate is its active ingredient in the streamside microbial communities of the upper sacramento river. Material safety data sheets 389 methyl isocyanate stable water, acid, alkali, amine, iron, tin, copper and their salts, other catalysts.
Methyl isothiocyanate mitc is a common soil fumigant byproduct that is a toxic and corrosive, skin and respiratory irritant. Sds of methyl isocyanate, safety data sheets, cas 624839. Summary the use and storage of methyl isocyanate mic. Methyl isocyanate is a dot poison inhalation hazard pih. Identification of the substancemixture and of the companyundertaking.
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